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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT1
All Species:
6.06
Human Site:
Y497
Identified Species:
11.11
UniProt:
Q96EB6
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96EB6
NP_001135970.1
747
81681
Y497
C
H
R
L
G
G
E
Y
A
K
L
C
C
N
P
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001087854
741
80936
Y491
C
H
R
L
G
G
E
Y
A
K
L
C
C
N
P
Dog
Lupus familis
XP_546130
745
81496
K495
R
L
G
G
E
Y
A
K
L
C
C
N
P
V
K
Cat
Felis silvestris
Mouse
Mus musculus
Q923E4
737
80353
G487
E
L
C
H
R
L
G
G
E
Y
A
K
L
C
C
Rat
Rattus norvegicus
Q5RJQ4
350
39301
F106
K
E
L
Y
P
G
Q
F
K
P
T
I
C
H
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508324
480
51688
P236
S
E
I
T
E
K
P
P
R
T
H
K
E
L
E
Chicken
Gallus gallus
NP_001004767
756
82614
T509
Q
R
L
G
S
E
Y
T
K
L
C
Y
N
S
V
Frog
Xenopus laevis
NP_001091195
710
78684
D459
I
E
L
L
G
D
C
D
V
I
I
N
E
L
C
Zebra Danio
Brachydanio rerio
Q7ZVK3
379
42296
E135
P
F
F
A
L
A
R
E
L
Y
P
G
Q
F
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477351
823
91818
L533
E
S
E
R
Q
S
Q
L
D
T
D
T
Q
S
I
Honey Bee
Apis mellifera
XP_395386
868
98678
T575
F
N
T
C
P
S
K
T
E
I
I
S
E
S
S
Nematode Worm
Caenorhab. elegans
Q21921
607
68747
I363
L
P
H
Y
N
A
D
I
E
L
L
G
N
C
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53685
503
57684
H259
S
V
F
Y
N
I
A
H
M
V
L
P
P
E
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
93.3
91.4
N.A.
85.1
23.4
N.A.
49.7
68.1
57.9
22.2
N.A.
37.2
39.9
31.3
N.A.
Protein Similarity:
100
N.A.
95.5
94.3
N.A.
90
33.3
N.A.
54.7
75.4
69.3
35
N.A.
52.2
55.9
47.5
N.A.
P-Site Identity:
100
N.A.
100
0
N.A.
0
13.3
N.A.
0
0
13.3
0
N.A.
0
0
6.6
N.A.
P-Site Similarity:
100
N.A.
100
0
N.A.
0
33.3
N.A.
0
6.6
20
0
N.A.
13.3
26.6
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
35.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
16
16
0
16
0
8
0
0
0
0
% A
% Cys:
16
0
8
8
0
0
8
0
0
8
16
16
24
16
16
% C
% Asp:
0
0
0
0
0
8
8
8
8
0
8
0
0
0
8
% D
% Glu:
16
24
8
0
16
8
16
8
24
0
0
0
24
8
8
% E
% Phe:
8
8
16
0
0
0
0
8
0
0
0
0
0
8
0
% F
% Gly:
0
0
8
16
24
24
8
8
0
0
0
16
0
0
0
% G
% His:
0
16
8
8
0
0
0
8
0
0
8
0
0
8
0
% H
% Ile:
8
0
8
0
0
8
0
8
0
16
16
8
0
0
8
% I
% Lys:
8
0
0
0
0
8
8
8
16
16
0
16
0
0
16
% K
% Leu:
8
16
24
24
8
8
0
8
16
16
31
0
8
16
0
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
16
0
0
0
0
0
0
16
16
16
8
% N
% Pro:
8
8
0
0
16
0
8
8
0
8
8
8
16
0
16
% P
% Gln:
8
0
0
0
8
0
16
0
0
0
0
0
16
0
0
% Q
% Arg:
8
8
16
8
8
0
8
0
8
0
0
0
0
0
0
% R
% Ser:
16
8
0
0
8
16
0
0
0
0
0
8
0
24
8
% S
% Thr:
0
0
8
8
0
0
0
16
0
16
8
8
0
0
0
% T
% Val:
0
8
0
0
0
0
0
0
8
8
0
0
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
24
0
8
8
16
0
16
0
8
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _